Breaking Up Blood Platelet Aggregates With Vitamin C

  Majid Ali, M.D. Children are invited to use the text and photographs (such as those below) on this web site for preparing competition essays and school science projects. Blood Platelet Clump Due to Oxidative Stress. Dissociation of Platelet Aggregates by Vitamin C   Figure 15 (top) shows patterns of aggregation of platelets induced by oxidative stress of epinephrine, collagen,

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AA Oxidopathy Part One

Majid Ali, M.D.   AA Oxidopathy: The Core Pathogenetic Mechanism of Ischemic Heart Disease PART I Majid Ali, M.D., Omar Ali, M.D. Ali M, Ali O. AA Oxidopathy: the core pathogenetic mechanism of ischemic heart disease. J Integrative Medicine 1997;1:1-112. From the Departments of Medicine, Capital University of Integrative Medicine, Washington, D.C., and Institute of Preventive Medicine, New York (MA

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AA OXIDOPATHY – PART 2 – Morphology

Majid Ali, M.D.     MORPHOLOGIC PATTERNS OF AA OXIDOPATHY Below we describe our high-resolution, phase-contrast morphologic observations that comprise AA oxidopathy and oxidative coagulopathy. The degree and extent of oxidative changes, of course, varies over a broad range depending on the number and the nature of oxidative stressors. During the early months of our work with AA oxidopathy, we

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AA OXIDOPATHY – PART 3

Majid Ali, M.D. Coronary Artery Heart Disease Begins With AA Oxidopathy      AA OXIDOPATHY HYPOTHESIS IS CONSISTENT WITH ALL KNOWN MOLECULAR DYNAMICS OF IHD     Molecular dynamics that preserve the clotting-unclotting equilibrium (CUE) of life are marvels of biology. An elaborate system of coagulative proteins, fibrinolytic enzymes and inhibitors of fibrinolysis exists in the circulating blood that prevents clotting-unclotting

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AA Oxidopathy References

  Majid Ali, M.D. SUMMARY Redox regulation in the circulating blood is a dynamic, elaborately integrated complex of diverse energetic-molecular events that involve all plasma and cellular oxidant-antioxidant systems. Changes of redox dysregulation in circulating blood comprise cell erythrocyte membrane damage and cell lysis, zones of plasma congealing, activation of polymorphonuclear leukocytes and monocytes, transformation of monocytes into macrophages, and

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AA Oxidopathy

Majid Ali, M.D.   Summary               Redox regulation in the circulating blood is a dynamic, elaborately integrated complex of diverse energetic-molecular events that involve all plasma and cellular oxidant-antioxidant systems. Changes of redox dysregulation in circulating blood comprise cell erythrocyte membrane damage and cell lysis, zones of plasma congealing, activation of polymorphonuclear leucocytes and monocytes, transformation of monocytes into

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Early Observations In Free Radical Pathology – Early History

Majid Ali, M.D. An Article of Course on Molecular Biology of Oxygen   In 1983, Eli Metchnikoff, a Russian biologist, made his seminal discovery of the role of phagocytes in host defense. His work provided the scientific basis for our current ideas of cellular host defense. During the five decades which followed Metchnikoff’s work, the investigative focus remained on the

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