AA OXIDOPATHY – PART 3

Majid Ali, M.D. Coronary Artery Heart Disease Begins With AA Oxidopathy      AA OXIDOPATHY HYPOTHESIS IS CONSISTENT WITH ALL KNOWN MOLECULAR DYNAMICS OF IHD     Molecular dynamics that preserve the clotting-unclotting equilibrium (CUE) of life are marvels of biology. An elaborate system of coagulative proteins, fibrinolytic enzymes and inhibitors of fibrinolysis exists in the circulating blood that prevents clotting-unclotting

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AA Oxidopathy References

  Majid Ali, M.D. SUMMARY Redox regulation in the circulating blood is a dynamic, elaborately integrated complex of diverse energetic-molecular events that involve all plasma and cellular oxidant-antioxidant systems. Changes of redox dysregulation in circulating blood comprise cell erythrocyte membrane damage and cell lysis, zones of plasma congealing, activation of polymorphonuclear leukocytes and monocytes, transformation of monocytes into macrophages, and

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AA Oxidopathy

Majid Ali, M.D.   Summary               Redox regulation in the circulating blood is a dynamic, elaborately integrated complex of diverse energetic-molecular events that involve all plasma and cellular oxidant-antioxidant systems. Changes of redox dysregulation in circulating blood comprise cell erythrocyte membrane damage and cell lysis, zones of plasma congealing, activation of polymorphonuclear leucocytes and monocytes, transformation of monocytes into

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Early Observations In Free Radical Pathology – Early History

Majid Ali, M.D. An Article of Course on Molecular Biology of Oxygen   In 1983, Eli Metchnikoff, a Russian biologist, made his seminal discovery of the role of phagocytes in host defense. His work provided the scientific basis for our current ideas of cellular host defense. During the five decades which followed Metchnikoff’s work, the investigative focus remained on the

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Molecular Biology of Oxygen and Oxygen Homeostasis

Majid Ali, M.D. Oxygen Homeostasis Columns Published inTownsend Letters   Full texts of these columns are posted at this site Ali M.  Respiratory-to-Fermentative (RTF) Shift in ATP Production in Chronic Energy Deficit States. Townsend Letter for Doctors and Patients. 2004. 253: 64-65 (2004). Ali M. Hydrogen peroxide therapies: Recent Insights into oxystatic and antimicrobial actions. Townsend Letter for Doctors and

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The Depression-Heart Link

Majid Ali, M.D. Evidence for Oxygen Models of Depression and Coronary Heart Disease My Oxygen Models of Depression and Coronary Heart Disease (CHD) are extensions of my Oxygen Model of Health and Disease. These are unifying models that explains all aspects of depression and CHD—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among

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Succinate Retention – Molecular Biology of Oxygen

Majid Ali, M.D. Below is the letter which I received about my Krebs Cycle Studies. [Nature] Your post has been approved Date: 6/19/2015 3:21:05 A.M. Pacific Daylight Time From: donotreply@nature.com Reply To: To: Send IM to: MajidAliMDmajidalimd@aol.com CC: BCC: Sent on: Sent from the Internet (Details ************ Dear Majid Ali, The following post you wrote on the Nature website has

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COMPLEMENTARITY AND CONTRARIETY in Lipidomics

Majid Ali, M.D. OUTLINE I. Introduction II. Lipidomics III. Structure and Classification of Lipids IV. Omega-3 and Omega-6 Fatty Acids V. Metabolism of Lipids VI. Phospholipids VII. Lipid Ecosystems VIII. The LDL-Oxidative Modification Hypothesis IX. The Oxidative Model of HDL Dysregulation X. Cholesterol as a Synapse Promoter XI. Lipids in Biomembranes XII. Eicosanoid Biology XIII. Biology of Prostaglandins XIV. Biology

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COMPLEMENTARITY AND CONTRARIETY in Glycomics

Majid Ali, M.D. OUTLINE I. Introduction II. Glycomics III. Complexities of Structure IV. Complexities of Function V. Cellular Glucose Oxidation VI. Carbohydrates and Generation of Reactive Oxygen Species VII. The Too-Much/Too-Little Sugar Dilemma VIII. Rapid Hyperglycemic-Hypoglycemic Shifts IX. Glucose Toxicity and Hexosamine Pathways X. Sugars and Prions XI. Sugars and the Inflammatory Response XII. Sugars, Adhesion Molecules, and Infections XIII.

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