Majid Ali, M.D. Coronary Artery Heart Disease Begins With AA Oxidopathy AA OXIDOPATHY HYPOTHESIS IS CONSISTENT WITH ALL KNOWN MOLECULAR DYNAMICS OF IHD Molecular dynamics that preserve the clotting-unclotting equilibrium (CUE) of life are marvels of biology. An elaborate system of coagulative proteins, fibrinolytic enzymes and inhibitors of fibrinolysis exists in the circulating blood that prevents clotting-unclotting
Read moreMajid Ali, M.D. SUMMARY Redox regulation in the circulating blood is a dynamic, elaborately integrated complex of diverse energetic-molecular events that involve all plasma and cellular oxidant-antioxidant systems. Changes of redox dysregulation in circulating blood comprise cell erythrocyte membrane damage and cell lysis, zones of plasma congealing, activation of polymorphonuclear leukocytes and monocytes, transformation of monocytes into macrophages, and
Read moreMajid Ali, M.D. Summary Redox regulation in the circulating blood is a dynamic, elaborately integrated complex of diverse energetic-molecular events that involve all plasma and cellular oxidant-antioxidant systems. Changes of redox dysregulation in circulating blood comprise cell erythrocyte membrane damage and cell lysis, zones of plasma congealing, activation of polymorphonuclear leucocytes and monocytes, transformation of monocytes into
Read moreMajid Ali, M.D. An Article of Course on Molecular Biology of Oxygen In 1983, Eli Metchnikoff, a Russian biologist, made his seminal discovery of the role of phagocytes in host defense. His work provided the scientific basis for our current ideas of cellular host defense. During the five decades which followed Metchnikoff’s work, the investigative focus remained on the
Read moreMajid Ali, M.D. Oxygen Homeostasis Columns Published inTownsend Letters Full texts of these columns are posted at this site Ali M. Respiratory-to-Fermentative (RTF) Shift in ATP Production in Chronic Energy Deficit States. Townsend Letter for Doctors and Patients. 2004. 253: 64-65 (2004). Ali M. Hydrogen peroxide therapies: Recent Insights into oxystatic and antimicrobial actions. Townsend Letter for Doctors and
Read moreMajid Ali, M.D. Evidence for Oxygen Models of Depression and Coronary Heart Disease My Oxygen Models of Depression and Coronary Heart Disease (CHD) are extensions of my Oxygen Model of Health and Disease. These are unifying models that explains all aspects of depression and CHD—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among
Read moreMajid Ali, M.D. Below is the letter which I received about my Krebs Cycle Studies. [Nature] Your post has been approved Date: 6/19/2015 3:21:05 A.M. Pacific Daylight Time From: donotreply@nature.com Reply To: To: Send IM to: MajidAliMDmajidalimd@aol.com CC: BCC: Sent on: Sent from the Internet (Details ************ Dear Majid Ali, The following post you wrote on the Nature website has
Read moreMajid Ali, M.D. OUTLINE I. Introduction II. Lipidomics III. Structure and Classification of Lipids IV. Omega-3 and Omega-6 Fatty Acids V. Metabolism of Lipids VI. Phospholipids VII. Lipid Ecosystems VIII. The LDL-Oxidative Modification Hypothesis IX. The Oxidative Model of HDL Dysregulation X. Cholesterol as a Synapse Promoter XI. Lipids in Biomembranes XII. Eicosanoid Biology XIII. Biology of Prostaglandins XIV. Biology
Read moreMajid Ali, M.D. One of My Succinate Stories
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