Category Archives: Respiratory-to-Fermentative (RTF) Shift

A Disease State Is Evolution-In-Reverse – A Bioenergetic View of the Nature of Chronic Disease

Majid Ali, M.D. In 2004, I coined the term respiratory-to-fermentative to define the bioenergetic basis of immune-inflammatory diseases. In the years following 2004, I extended my studies of Krebs cycle metabolites and reported the presence of the respiratory-to-fermentative (RTF) shift to varying degrees in all chronic disorders in which I examined Krebs cycle metabolism with 24-hour urinary excretion of Krebs

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