: Majid Ali, M.D. Oxygen Governs the Production and Functions of growth factors, Which Preserve the Health of Cell Populations of the Body. “It seems that growth factors may instruct blood-cell progenitors to develop into specific mature cell types, actively determining lineage choice. But is this reductionist view of cell fate overly simplistic?” The above quote is taken from an
Read moreMajid Ali, M.D. The Oxygen Model of Holism in Integrative Medicine is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explain all aspects of the multiple disease processes that may co-exist as co-morbidities—clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1)
Read moreMajid Ali, M.D. Krebs Cycle is a cycle of cellular catalysts that break down food substances to release ATP energy. Since all chronic diseases are energy dysfunctions, they can be considered to be Krebs cycle disorders. Of central importance in cellular energetics is the Krebs (citric acid, tricarboxylic acid) cycle. In health, this cycle is the true crossroads of both anabolic
Read moreMajid Ali, M.D. Pain is oxygen hunger of cells. Oxygen is the organizing influence of human biology and governs the aging process. In 2000, I began Oxygen and Aging1 with those words. Oxygen is a master work of nature — an enduring tribute to Nature’s preoccupation with complementarity and contrariety. It is an elixir of life and a hemlock for death
Read moreMajid Ali, M.D. My Oxygen Model of Diseases are extensions of my Oxygen Model of Health and Disease. It is a unifying model that explains all aspects of chronic diseases—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s
Read moreMajid Ali, M.D. How can there be a single model of all diseases? I anticipate the question. Aren’t medical models proposed to reduce complexities of scientific knowledge of human biology to workable simplicities in clinical medicine? I expect that question as well. If there is a single model for all chronic disease, doesn’t that mean that there would a single
Read moreMajid Ali, M.D. Below is a list of elected citations relevant to molecular biology of oxygen from my own writings and from other sources. 1. . Ali M. Spontaneity of Oxidation in Nature and Aging. Monograph, Teaneck, New Jersey, 1983. 2. Ali M. The agony and death of cell. Syllabus of the Instruction Course of the American Academy of Environmental
Read moreMajid Ali, M.D. I offer two courses on molecular biology of oxygen: 1. Molecular Biology of Oxygen Basics 2. Molecular Biology of Oxygen Advanced Each course comprises tutorials, each of which stands on its own and links with materials in others to complete the “oxygen kaleidoscope.” Individuals interested in the study of the core issues of dysfunctional oxygen metabolism, these two courses included tutorials devoted
Read moreMajid Ali, M.D. Our planet is oxygen-depleted and fermenting now and so is life on it. Ours is not the first epoch of oxygen-depletion and fermentation. What might such epoch of the past tell us about the shape of things to come? Oxyphils-Oxyphobes Conflicts In our toxic preoccupation with daily intramural murders, we are missing the central story of our
Read moreMajid Ali, M.D. Oxygen seldom comes up in deliberations of depression of mental health professional. This is a serious omission which exacts a heavy toll from people who suffer from depression. I have taken care of a large number of patients with varying degrees of depression, including those attempted to take their lives rather than continue to suffer from it. They have
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