Category Archives: Evolution in Reverse

Succinate As the Dominant Player in Krebs Cycle Bioenergetics

Majid Ali, M.D.  Succinate Circa 2004 Table 1. The Frequency of Increased* Urinary Excretion of Metabolites of the Krebs Cycle in 236 Patients with Dysoxygenosis Citric acid Succinic acid Aconitic acid Fumaric acid 2-oxo-glutaric acid 196 40 26 1 0 * Increases beyond the laboratory range for the general population. Levels of acids measured in mmol/mol creatinine. Succinate Circa 2015

Read more

Disease Is Evolution-in-Reverse

Majid Ali, M.D. To understand the beginning of diseases, we first need to understand the beginning of life. This is impossibly complex one way and very simple in an another. Simply stated, evolution is the long (and continuing journey) which allowed the development of modern human cells from the primordial “pre-cells” (spherules that lived in he toxic primordial soup). Pre-cells were

Read more

THE DYSOX MODEL OF ADRENAL HEALTH AND DISEASE

THE OXYGEN MODEL OF ADRENAL DYSFUNCTION Majid Ali, M.D. The intellectual disconnect between endocrinologists and the reality of adrenal dysfunction is breathtaking. In my columns, I strive hard not to subordinate ethics to ideology. Ethics, simply stated, is the study of the consequences of one’s action on others. Ethics is also the study of the consequences of one’s inaction on others

Read more