Category Archives: Cell Membrane Receptors

The Oxygen Model of Every Chronic Disease

Majid Ali, M.D. How can there be a single model of all diseases? I anticipate the question. Aren’t medical models proposed to reduce complexities of scientific knowledge of human biology to workable simplicities in clinical medicine? I expect that question as well. If there is a single model for all chronic disease, doesn’t that mean that there would a single

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Catabolic Maladaptation: Insulin Toxicity By Another Name

Majid Ali, M.D. In the late 1980, before I recognized the full significance of deranged insulin signaling on health, I coined the term catabolic maladaptation to refer to an abnormal state of metabolism that causes obesity. It took The Journal of American Medical Association over 25 years to recognize catabolic maladaptation as the true nature of obesity. Below, I present

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What is Insulin Resistance?

Majid Ali, M.D. Insulin resistance is a state in which cells in the body do not respond to actions of insulin in the blood. Insulin sends signals to the cells of the various body organs not only for cellular energy generation and utilization but for many other functions.  In 2000, to explain the primary metabolic role of insulin hormone on cells, I

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Oxidative Cell Membrane Injury

Oxidative Cell Membrane Injury Majid Ali, M.D.   A cell looks at the world around it through its plasma membrane. A human frame is but a zillion plasma membranes at the surface of and within the confines of cells aligned in an infinite variety of kaleidoscopic mosaics. Health preservation for man, then, is the preservation of the integrity of a

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