Oxygen Course – Majid Ali, M.D. – – -Introduction


Oxygen homeostasis determines the state of health. Disruption of oxygen homeostasis lead to absence of health and disease.


Impeded Oxygen Signaling

I coined the term oxygen signaling for all cues and commands given by oxygen, or its absence, to cells and tissues for energetic, buoilding or dismantling reactions.

Impeded oxygen signaling is the fundamental energetic-molecular derangement in all chronic states of absence of health and disease. In 1999, I introduced the term dysoxygenosis for a state of oxygen dyshomeostasis in which the fundamental energetics of the human biology are disrupted by impaired function of core enzymes involved in oxygen homeostasis (oxyenzymes) and altered expressions of genes maintaining that order (oxygenes).11-14 The core concept of dysoxygenosis evolved through reflections on the subjects of spontaneity of oxidation in nature, the many faces of oxygen, and clinical consequences of chronic cellular oxidosis and acidosis during a period of nearly three decades. The clinical, morphologic, and biochemical observations made during those years were the subjects of a series of previous publications.6-33 Most of those articles can be accessed from  www.majidali.com.

Since the fundamental energetic-molecular lesion in all states of absence of health is oxygen dyshomeostasis, it follows that the primary focus of all clinicians in health preservation and reversal of chronic disease must be restoration of oxygen homeostasis. In acute illness, prompt attention to the specific lesion(s), of course, is essential. Focus on issues of oxygen homeostasis can significantly improve clinical outcomes in those illnesses as well. I present the various aspects of the subject of oxystatic therapies —measures that restore oxygen homeostasis—in each of the eight volumes of this textbook.

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