Oxygen Signaling
Majid Ali, M.D.
I coined the term oxygen signaling to refer to all biological roles of oxygen in which the presence or absence of oxygen triggers, perpetuates, modifies, suppresses, or terminates biologic reactions with or without direct involvement of energy generation, utilization, conservation, or storage.
Oxygen Is the Organizing Principle of Human Biology and Governs the Aging Process
In started my book, Oxygen and Aging (2000) with the above words (ref. 1). Two years earlier, I introduced the term dysoxygenosis (dysox for short” for dysfunctional oxygen metabolism as a state of disrupted oxygen signaling. (ref. 2) Specifically, it includes: (1) oxygen-driven cellular energetics; (2) oxygen-driven detox pathways; (3) oxygen signaling for cellular development, differentiatiomn, and demise; and (4) oxygen detergent functions.
Darwin and Dysox Trilogy
I refer physicians and other readers with special interest in deeper understanding of molecular biology of oxygen, as well as the pertinnet citations to Darwin and Dysox Trilogy(2009), the tenth, eleventh, and twelfth volumes of my textbook entitled The Principles and Practice of Integrative Medicine.
Oxygen’s Three-legged Throne
The Oxygen Model of Disease is a unifying model of enormous explanatory power—for understanding the basic nature of the disease processes, as well as for designing testable, rational, and scientifically sound integrative plans for restoring health. Specifically, I point here that the common denominator in the cause of all non-developmental disorders is cellular dysox (dysfunctional oxygen homeostasis). Every pain is some cells’ cries for oxygen. Cellular dysox is the primary cause of all disease-causing inflammation, which sets the stage for the beginnings of all forms of bowel disorders, liver injury, asthma, allergy, colitis, heart disease, stroke, kidney failure, cancer, and degenerative disorders.
The Oxygen Model of Disease
The Oxygen Model of Disease is a unifying model of enormous explanatory power—for understanding the basic nature of the disease processes, as well as for designing testable, rational, and scientifically sound integrative plans for restoring health.
For citations and detailed information on the biology of oxygen, I refer professional readers to Darwin, Oxygen Homeostasis, and Oxystatic Therapies (2009), the tenth, volume of my textbook entitled The Principles and Practice of Integrative Medicine.
Oxygen Is the Organizing Principle of Human Biologyand Governs the Aging Process
Dysox (dysoxygenosis) is a state of disrupted oxygen signaling. Specifically, it includes: (1) oxygen-driven cellular energetics; (2) oxygen-driven detox pathways; (3) oxygen signaling for cellular development, differentiatiomn, and demise; and (4) oxygen detergent functions.
k Oxygen-driven cellular energetics
k Oxygen-driven detox pathways
k Oxygen signaling for cellular development
k Oxygen signaling for cellular differentiatiomn
k Oxygen signaling for cellular demise
k Oxygen detergent functions
Dumbing Down Science
The inclusion of oxygen in the title of this article on Crohn’s disease may seem odd to some readers. Doctors do not look at this disease—nor at any other disease, for that matter—through the prism of oxygen homeostasis. So, it is not surprising that people in general do not think of oxygen when they think of Crohn’s disease. Doctors can disregard oxygen only at the cost of dumbing down science of their profession. I assert that the last thing we can afford to dumb down in healing arts is the science of medicine.
Below is text from my forthcoming book entitled Darwin’s Drones, Oxygen, and Diabetes: to make my larger point:
In our toxic preoccupation with daily intramural murders, we are missing the central story of our time: an epic planetary struggle between the oxygen-loving (“oxyphils”) and oxygen-shunning species (“oxyphobes”) and the incremental victories of the latter. A monumental tragedy of mass extinction of species is playing out on the global stage. Oxygen-loving frogs and related amphibian species are being decimated by oxygen-shunning fungi. The oxygen-shunners are also responsible for the plight of butterflies, bees, and bats—for disappearing butterflies, collapsing bee colonies, and bat that fly out of their caves in daylight and drop dead. Their fungus-ridden noses foretell things about the shape of the future.
For hundreds of thousands of years, the planet Earth was in equilibrium in terms of its acid-alkali balance, oxidant-antioxidant regulation, and atmospheric gas homeostasis. Now it is fermenting because it is:
k Chemicalizing;
k Acidifying;
k Oxidizing;
k Carbonizing; and
k Deforesting (Earth’s “De-lunging)”
Humans are also fully engaged in this struggle, and losing with spreading epidemics of mystery maladies—chronic fatigue, brain fog, fibromyalgia, polycystic ovary syndrome, gender devolution, memory deficits, and rising incidences of cancer. Regrettably, the main body of physicians, under the influence of The New England Journal of Medicine,is totally oblivious to the man-microbe conflicts that are at the root of these disorders.
The observable elements of climatic chaos—as well as those that will almost certainly occur—are further shifting the equilibrium in the favor of oxyphobes and against oxyphils. Among the most vulnerable on the planet are its children.
In 1994, 94 pounds of synthetic chemical were produced for every child, man, and woman worldwide in the United States. The planetary acidification and oxidation is being caused by incremental chemicalization and carbon dioxide accumulation. Forests, shrubs, and gases are the Earth’s lungs—exchanging carbon dioxide for oxygen—and spreading deforestation is literally planetary de-lunging.
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