Magnesium for Mitochondrial Health
Majid Ali, M.D.
Mitochondria are structures in the cells that generate ATP energy. Magnesium is essential for mitochondrial health.
Adenosine triphosphate (ATP) is the cellular energy currency. In health, the concentration of ATP in respiring cells is considerably higher than that of its precursors, adenosine biphosphate (ADP) and adenosine monophosphate (AMP). During periods of heightened energy demands, ATP is hydrolyzed to ADP with release of energy to fulfill the increased demands of energy. As a consequence, the cellular ATP/ADP ratio is reduced, the rate of glycolysis is increased, mitochondrial respiration is speeded, and oxidative phosphorylation of ADP to ATP occurs to build back ATP levels. Evidently, that mechanism increases ATP at the expense of reducing ADP which, in turn, serves as the signal for ATP-mediated phosphorylation of AMP to generate ADP. All of those phosphate transfer reactions are mediated by magnesium.
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