The Oxygen Model of Every Chronic Disease

Majid Ali, M.D.

How can there be a single model of all diseases? I anticipate the question. Aren’t medical models proposed to reduce complexities of scientific knowledge of human biology to workable simplicities in clinical medicine? I expect that question as well. If there is a single model for all chronic disease, doesn’t that mean that there would a single treatment for all chronic diseases? Isn’t that simple-minded to propose such a frivolous answer. These are also questions that Charles Darwin once faced. I want in Darwin’s foot steps and do expect some of the mockery that he confronted.


Oxygen is the primary nutrient for humans. Darwin would have recognized that. Perhaps he did but left no record of that. Or, he was not a physician and did not tangle with them as well. So I am neither surprised nor discouraged by some snickering on the words of the title of this article.


Below, I state my Oxygen Model of Every Chronic Diseases and invite readers to consider the facts of human biology presented in this and related article in which I present oxygen models of specific diseases (search words: Dr. Ali’s Oxygen Models of Diseases) and marshal evidence to support them. Later in this article, I present some texts from an article published in science journal Nature to make one essential point in all aspects of health and disease.


Oxygen Model of Every Disease

My Oxygen Model of Every Chronic Disease is a unifying model that explains all aspects of every chronic disease—causes, clinical course, consequences, and control—on the basis of impaired and dysfunctional oxygen homeostasis. The most important among oxygen’s health-preserving and disease-reversing roles are:

1. Oxygen signaling which governs all cellular conversations;

2. Oxygen’s mitochondrial ATP energy generating functions;

3. Oxygen’s cellular-grease removing (detergent functions);

4. Oxygen’s cellular detox functions;

5. Oxygen-regulated cell membrane and matrix functions; and

6. Oxygen’s cellular repair roles. 


The Oxygen Model of Every Chronic Disease provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of all chronic diseases.


The crucial importance of the Unifying Oxygen Model of Every Disease is that it:

* Explains the scientific basis of physiology and pathology of all body organs;

* Sheds light on the central roles of dysfunctional oxygen homeostasis in all contributory causative factors of every chronic disease;

* Elucidates how toxicities of foods, environments, and thoughts set the stage for evey chronic disease by mechanisms governed by oxygen;

* Reveals the oxygen-regulated mechanisms by which various detox therapies restore functions of nerves;

* Allows the formulation of rational and effective designs for reversing every chronic disease; and

* Provides explanations of mechanisms by which time-honored natural remedies work by restoring oxygen homeostasis work.


“The nature-versus-nurture debate about human potential will be familiar to most. A similar dispute surrounds the role of environmental signals, such as growth factors, in determining cell-type identity in multicellular organisms. Two papers, one by Rieger et al.1 published in Science, and the other by Sarrazin et al.2 in Cell, inform this discussion by providing evidence that environmental cues might actively determine cell lineage.”

                                                    Nature. September 10, 2009

All environmental signals in the body, of course, and governed by oxygen.


Next consider this text from the same article:

“The process of lineage specification is fundamental to the development and maintenance of tissues in multicellular organisms. Blood formation, or haematopoiesis, exemplifies this. Here, rare multipotent stem cells and progenitor cells that reside in the bone marrow produce several different lineages of mature blood cell. In steady-state conditions, haematopoiesis accommodates a ferociously high rate of cell turnover, with millions of cells being generated every second. In addition, blood cells are produced at speed ‘on demand’ in response to injury or challenge — for instance, red blood cells in response to bleeding or white blood cells in response to infection.”

All environmental signals for the process of lineage specification are also governed by oxygen.


Next consider this text from the same article:

“However, the physiological relevance of these results remains uncertain. Rieger and colleagues’ experiments were carried out in artificial cell-culture systems using high concentrations of single growth factors, whereas decisive experiments will require faithful mapping of the fate of single cells in live animals — this is currently not possible in mammalian models such as mice. Those caveats aside, this work1 elegantly demonstrates the importance and power of high-resolution imaging of cell fate at the single-cell level.”


Please enter the following in you search box to access my articles marshaling evidence for my oxygen models of diseses.

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