Molecular Biology of Oxygen

Majid Ali, M.D.

Many physician-friends ask about what I do. They know I competed my certification in surgery in London (FRCS) in the late 1960s and my certification in anatomic and clinical pathology in early 1970s. They are aware of my work as chief pathologist in a New Jersey hospital and at Columbia University in New York for some decades. They have heard of my publications in the fields of immunology, allergy, and clinical ecology.

Many years ago, Professor Amin Malik, my roommate at Kind Edward Medical School, Lahore, Pakistan, and professor of urology at Uinversity of Louisville, Kentucky, said,

“Majid, I hear a lot about you but don’t know what you do. Tell me what do you do?”

“I try to help my patients with natural therapies,” I replied.

“What do you call it?”

“Holistic medicine.”

“Don’t tell me that. I heard about that back in 1958, when I first met you. I want to know you do, really?”

“Really, that’s what I do,” I replied with a laugh.”

“No, that is not what you. You can’t be just prescribing herbs and giving colonics. This much I know. I want to know what you really do.”

” Do you want me to make up something? Is that it?” I laughed some more.

“Yes. Yes. Make up something for me that makes some sense to me,” he pressed with penetrating eyes.

“Okay, then I will call it molecular biology of oxygen. There, I just invented a new medical speciality.”

He stared at me for several moments. I stared back at him, amused by his seeming bewilderment. Then he grinned broadly and said,

“Molecular biology of oxygen, did you just make it up?”

“Yes.” I shrugged.

“Molecular biology of oxygen,” he spoke slowly, as if to reassure himself that he heard what I said.

‘Okay, so be it. Molecular biology of oxygen it will be.”

Below is text from one of other articles which might interest readers.

Oxygen Eureka Moment

My “oxygen eureka” moment” occurred sometimes during the mid 1970s. In a flash, I saw that nature chose oxygen to drive all aspects of human evolution. If it were to be proven to be true, then the hand of oxygen must be recognizable in all the fundamental energetic cause of all chronic disease. It would take several years before I fully understood the true clinical significance of two faces of the moment: First, the core cause of every chronic illness is rooted in oxygen dysfunctions; and (2) Second, no treatment plans for any chronic disease can be considered complete without detecting and addressing all threats to oxygen homeostasis.

I breathed and lived with my oxygen eureka moment for the next four decades, as a surgical pathologist, clinical pathologist, clinical ecologist, molecular biologist, a student of cellular bioenergetics, and a holistic practitioner. Eventually, this work led to the publication of fourteen volumes of my textbook The Principles and Practice of Integrative Medicine. For practitioners and scientists interested in a suggestion where to begin reading this textbook, I suggest the triology of 10th, 11th, and 12th volumes entitled “Darwin, Dysox, and Disease.” For the general reader, I suggest my book Aging and Oxygen (2000), available at

Oxygen Model of Health and Disease

My Oxygen Model of Health and Disease is a unifying model that explains all aspects of health, disease, and healing—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.

The Oxygen Model of Health and Disease provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of every state of health and absence of health.

The crucial importance of the Unifying Oxygen Model of Disease is that it:

* Explains the scientific basis of primary aging processes in the body;

* Sheds light how health can be preserved by addressing all oxygen-related issues;

* Elucidates how toxicities of foods, environments, and thoughts cause tissue injury and disease;

* Reveals the mechanisms by which various detox therapies work (Oxygen is the primal detergent which

          removes cellular grease and allows cells to breathe freely).

* Allows the formulation of rational and effective designs for reversing chronic diseases; and

* Provides explanations of mechanisms by which time-honored natural remedies work.


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