Toxic Womb Ecology and Newborn’s Immunity
Majid Ali, M.D.
My purpose in offering my “Toxic Womb Ecology Library of Articles” is make my readers aware of the fact that many health disorders of the children are rooted in the toxic womb ecology. Since I consider immunity to be the body’s ability to preserve health and fight off chemical and microbial threats to health, I expect that ongoing scientific advances will delineate the various aspects of the mother-infant immune links.
Simply stated, incremental toxicities of the wombs are incrementally threatening the health of the unborn babies.
From my basic understanding of the evolutionary model of life, it has been possible for me to predict the ecologic relationships between the maternal womb ecology and the bowel-blood-liver ecosystems of children bodies. Below, I include the abstract of an important recent article that furnishes important new information on the subject. Readers can access articles in my Toxic Womb Ecology Library of Articles on the following websites:
Potential Role of the Intestinal Microbiota of the Mother in Neonatal Immune Education
Proc Nutr Soc. 2010; 69(3):407-15
Donnet-Hughes A; Perez PF; Doré J, et al. Nutrition and Health Department, Nestlé Research Centre, Nestec Ltd, PO Box 44, 1000 Lausanne 26, Switzerland.
Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer’s patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.