Oxygen Model of Alzheimer’s Disease


Majid Ali, M.D.

Alzheimer’s disease is caused by dysfunctional oxygen metabolism in the brain resulting from toxicities of foods, environments, and thoughts. In 1994, I proposed the oxidative model of Alzheimer’s disease in my book RDA Rats, Drugs and Assumptions.  Some years later I expanded that model to focus on oxygen homeostasis and designated it as The Oxygen Model Alzheimer’s Disease.  I provided the scientific basis of this model in my book Oxygen and Aging (2000). This is a unifying model that: (1) integrates all verifiable aspects of the prevailing models of the disease; and (2) offers a rational and scientifically sound integrative management plan. The core tenet of the model is that all relevant oxygen-related issues must be addressed to maximize the potential benefits.

Ten years later, the need and clinical value of this model should be far clearer. In August 2010, a special panel at the National Institutes of Health reviewed all available literature on the treatment of Alzheimer’s disease and confirmed what I have known for years: there are no effective drug therapies for the disease. Consider the following quote from a report on the panel’s conclusion published in The New York Times of August 28, 2010: “But the jury’s verdict was depressing and distressing. So far, nothing has been found to prevent or delay this devastating disease, which ceaselessly kills brain cells, eventually leaving people mute, incontinent, unable to feed themselves, unaware of who they are or who their family and friends are.” Some weeks earlier the Times had reported that PET brain scan and a spinal fluid protein test can predict with near certainty the development of Alzheimer’s disease ten to fifteen years earlier.

Theories of Alzheimer’s Disease

Below, I list the prevailing theories of Alzheimer’s disease.

1. The cholinergeic hypothesis

2. The amyloid hypothesis

3. The TAU hypothesis

4. The inflammatory hypothesis

5. The autoimmunity hypothesis (vaccines)

6. The genetic hypothesis

7. The Oxidative Model (which I published in 1995)

8. The Oxygen Model of dysox hypothesis in Oxygen and Aging in 2000. oxygen

A deep examination of each theory shows that its underlying mechanisms are related to cellular dysox (dysfunctional oxygen metabolism. Specifically, dysox it includes derangements of : (1) oxygen-driven cellular energetics; (2) oxygen-driven detox pathways; (3) oxygen signaling for cellular development, differentiatiomn, and demise; and (4) oxygen detergent functions.

Since publishing this model, my colleagues at the Institute of Integrative Medicine and I have applied it in the care of over fifty patients in varying stages of the disease. We observed fair to modest results in many patients with early and intermediate stages of the disease, but failed to help any patients with advanced stages of the disease.

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