The Oxygen Model of Systemic-Exertion-Intolerance Disease (SEID) and Chronic Fatigue Syndrome

Majid Ali, M.D.

Simply stated, my Oxygen Model of SEID and Chronic Fatigue Syndrome states that persistent chronic fatigue results from disturbed oxygen functions and predicts that all oxystatic therapies effectively administered will relieve chronic fatigue symptoms and eventually restore health. I coined the term oxystatic therapy for any therapy that restores oxygen functions.


In scientific terms, the Oxygen Model of Chronic fatigue Syndrome is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explains all aspects of SEID—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.

The Oxygen Model of SEID (CFS) provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features of SEID (Chronic fatigue Syndrome).

The crucial importance of this Unifying Oxygen Model of SEID is that it:

* Explains the scientific basis of primary energy dysfunctions in the body;

* Sheds light how health can be preserved by addressing all oxygen-related issues;

* Elucidates how toxicities of foods, environments, and thoughts cause energy deficits and SEID;

* Reveals the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely).

* Allows the formulation of rational and effective designs for reversing chronic diseases; and

* Provides explanations of mechanisms by which time-honored natural remedies work.


For my guidelines for recovering from SIED (chronic fatigue syndrome, also called ME syndrome), please consider my free course entitled “Dr. Ali’ SEID-Fatigue Course.”

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