Evidence for Oxygen Models of Asthma and Bowel Ecology

Majid Ali, M.D.

Asthma is rooted in disrupted gut ecology. Therefore I consider all treatments of asthma scientifically inadequate and clinically insufficient unless all relevant gut issues are effectively addressed, most importantly the restoration of altered gut ecology, for which I described my Seed, Feed, and Weed Approach (do a web search for my articles and videos on the subject for details).

I recognized the gut-asthma links and started write about it soon after I published my monograph entitled “Altered States of Bowel ecology” in 1987. Initially my view was based on personal clinical and laboratory observations related to asthma, mold allergy, and gut fermentation. Later I recognized that all my patients with asthma had objective laboratory evidence of impaired mitochondrial function in terms of reduced ATP generation. I presented these subjects at length in Integrative Immunology and Allergy, the fourth of my twelve volume textbook entitled “The Principles and Practice of Integrative Medicine” (1998, 2nd edition 2005, Canary 21 Press, available at www.aliacademy.org).

Scientific Evidence for the Asthma-Gut Links

Both my Oxygen Model of Impaired Gut Ecology and the Oxygen Model of Asthma are extensions of my Oxygen Model of Health and Disease. They are unifying models that explains all aspects of the two diseases—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.

The Oxygen Model of Impaired Gut Ecology and the Oxygen Model of Asthma provide simple models that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity.

The crucial importance of the Unifying Oxygen Models of Impaired Gut Ecology and asthma is that they:

* Explain the scientific basis of primary aging processes in the body;

* Shed light how health can be preserved by addressing all oxygen-related issues;

* Elucidate how toxicities of foods, environments, and thoughts cause tissue injury and disease;

* Reveal the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely).

* Allow the formulation of rational and effective designs for reversing chronic diseases; and

* Provide explanations of mechanisms by which time-honored natural remedies work.

Recent Evidence for the Gut-Asthma Connection

Clear evidence for the Oxygen Model of Impaired Gut Ecology and the Oxygen Model of Asthma was presented at annual 2015 conference of meeting of American Academy of Allergy, Asthma & Immunology. Below is an abstract of that report posted on the website of Medscape Medical News.


HOUSTON — Technological advances are transforming how many physicians think about allergy and asthma. Delegates attending this year’s American Academy of Allergy, Asthma & Immunology (AAAAI) conference will hear how the microbiome could change disease management.

“They’re now using DNA techniques, measuring certain types of RNA that only occur in bacterial or viral species,” meeting program chair Paul Williams, MD, from the Northwest Allergy & Asthma Center in Mount Vernon, Washington, told Medscape Medical News.

“There are millions of organisms inhabiting the gastrointestinal tract that we didn’t know about,” he explained. “It’s not only the species that is important; even the strain of bacteria and the collection are important because they interact with each other and they interact with diet. All of that plays a role in inflammation and immune response.”

During the meeting, delegates will be guided through the hygiene hypothesis to the more murky details of the link between gut microflora and asthma and allergies.

A plenary will look at how the microbial environment influences the development of allergic diseases, an oral abstract session will highlight some of the links between infant and maternal microbiome and allergen exposure, and a translational symposium will examine how microbiome discoveries could guide future probiotic regimens for the treatment and prevention of food allergy and atopic dermatitis.

There are millions of organisms inhabiting the gastrointestinal tract that we didn’t know about.

“The concept of the microbiome and the gut is getting another wave, if you will, because there’s more science now. It’s a very trendy topic,” said Mary Beth Fasano, MD, from the University of Iowa Carver College of Medicine in Iowa City, who is vice chair of the annual meeting program subcommittee.

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