The Roundup-Gluten Sensitivity Connection

Majid Ali, M.D.

An estimated five percent of Americans are gluten-intolerant. Here is the crucial question: Why did the grain that more than any other grain (wheat) sustained the proliferation of the human species and its spread all over the planet become so toxic during the last fifty years or so? My answer: the world now is overchemicalized, over-angerization, and overpopulated. Human guts are fermenting on a fermenting planet. MIT scientists Anthony Samsel and Stephanie Seneff proposed that Roundup herbicide was responsible for the gluten epidemic. Deeply respectful of the work of Drs. Samsel and Stephanie, I do not see how we can blame on one herbicide when humankind is sinking in a toxic pool of thousands of chemicals.


Exclusion of gluten foods from their diet relieves to varying degrees (often only temporarily) the following symptoms: nausea, bloating, GERD, diarrhea, skin rashes, and problems of mood, memory, and mentation. The reported clinical features also include symptoms related to dysfunctions of the thyroid and other organs.


The following quote from an article by MIT scientists Anthony Samsel and Stephanie Seneff is noteworthy:

“Here, we propose that glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully explained by the known effects of glyphosate on gut bacteria. Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with celiac disease can be attributed to glyphosate’s strong ability to chelate these elements. Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease match glyphosate’s known depletion of these amino acids. Celiac disease patients have an increased risk to non-Hodgkin’s lymphoma, which has also been implicated in glyphosate exposure. Reproductive issues associated with celiac disease, such as infertility, miscarriages, and birth defects, can also be explained by glyphosate. Glyphosate residues in wheat and other crops are likely increasing recently due to the growing practice of crop desiccation just prior to the harvest. We argue that the practice of “ripening” sugar cane with glyphosate may explain the recent surge in kidney failure among agricultural workers in Central America. We conclude with a plea to governments to reconsider policies regarding the safety of glyphosate residues in foods.”

Reference: Anthony Samsel, Stephanie Seneff, Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol. Dec 2013; 6(4): 159–184.

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