The Oxygen Model of Chronic Fatigue Syndrome

Majid Ali, M.D.

My Oxygen Model of Chronic Fatigue Syndrome (CFS) is an extension of my Oxygen Model of Health and Disease. It is a unifying model that explains all aspects of CFS—causes, clinical course, consequences, and control—on the basis of disturbed oxygen function. The most important among these compromised and/or blocked functions are: (1) oxygen signaling; (2) oxygen’s ATP energy generation; (3) oxygen’s detergent functions; (4) oxygen’s cellular detox functions; (5) oxygen-regulated cell membrane and matrix functions; (6) oxygen’s cellular repair roles.

The Oxygen Model of CFS provides a simple model that allows physicians to reduce complexities of diverse clinical syndromes into a workable simplicity. Readers who have read my article on the Oxygen Model of Fibromyalgia will recognize that in reality my Oxygen Model of Fibromyalgia and Oxygen Model of CFS are the same. This is so because Fibromyalgia and CFS are the two faces of the same disorder.

This model predicts that ongoing research will reveal that components of acidosis (excess acidity), oxidosis (increased oxidative stress), and CUD (clotting-unclotting dysequilibrium) will be found to play important roles in the pathology and clinical features (tissue pain and trigger points, disabling fatigue, and the problems of mood, memory, and mentation) of CFS.

The crucial importance of the Unifying Oxygen Model of CFS is that it::

Explains the scientific basis of primary aging processes in the body;

Sheds light how health can be preserved by addressing all oxygen-related issues;

Elucidates how toxicities of foods, environments, and thoughts cause tissue injury and disease;

Reveals the mechanisms by which various detox therapies work (Oxygen is the primal detergent which removes cellular grease and allows cells to breathe freely).

Allows the formulation of rational and effective designs for reversing chronic diseases; and

Provides explanations of mechanisms by which time-honored natural remedies work.


1. All symptoms of fibromyalgia are caused by cellular oxygen deprivation.

2. Oxygen deprivation is caused by dysfunctional oxygen metabolism.

3. Oxygen metabolism becomes abnormal due to excessive and cumulative oxidative stress caused by sugar overload, antibiotic abuse, undiagnosed allergies, synthetic chemicals, and anger.

Dysfunctional oxygen metabolism is not merely lack of oxygen in the air we breathe, in the blood, or in the cells. This is a critical distinction. I coin this term for a much deeper problem of oxygen metabolism within the cells that involves failure of enzymes involved in oxygen metabolism. This also forms the core of my ODD theory of the fibromyalgia/fatigue complex (ODD stands for oxidative-dysoxygenative dysfunction).

3 R’s OF CFS

* Fibromyalgia is Real.

* Fibromyalgia is Reversible.

* Fibromyalgia cannot be Reversed with drugs.

Reversal of Chronic Fatigue Syndrome

I describe my full program in a 90-minute DVD available from

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