The Oxygen Model of Alzheimer’s Disease
Majid Ali, M.D.
Alzheimer’s disease (AD) is a condition of brain cell loss that results in shrinking of the brain. It robs the person of his personality, memory, judgment, dignity, and identity. AD leaves its victims helpless , leaves them and hapless, unable to care for themselves or anyone else. Men and women with AD lose their spouses, and their spouses lose them. Alzheimer’s disease usually takes lives of individuals affected by it at a slower rate than most cancers that return after surgery. So, it is the most heart-wrenching problem faced by the family members who care for the individual.
What causes Alzheimer’s disease?
Is it bad diet? Yes, there is considerable evidence to support that view. Could it be deficiencies of essential nutrients? Yes, there is evidence for that as well. Could it be tobacco smoking? Yes, that too. How about lead and mercury toxicity? Certainly. Do many environmental pollutants injure brain cells and destroy them? Undoubtedly.
Do hypertension, obesity, and diabetes increase the risk and prevalence of Alzheimer’s disease? There is no doubt of that. Do chronic inflammatory and immune disorders increase the prevalence of the disease? Yes. Does emotional stress at home lead to memory loss? And work-related stress? And the quality of drinking water? Air quality? And how might habitual mental laziness affect the memory function? There is, of course, evidence for that?
Are strokes associated with a higher risk of Alzheimer’s disease? How often does chemotherapy diminish memory status? Do coronary bypass operations increase the risk of memory loss? And autoimmune disorders? And inflammatory disorders? The answer to all these questions is clearly yes.
Here is the crucial question: Can you think of some basic molecular-energetic defect that links the risk and prevalence of Alzheimer’s disease with all of the above facts? Yes. It is dysoxygenosis—dysox for short, dysfunctional oxygen metabolism for general readership.
The Oxygen Model of Alzheimer’s Disease
I proposed the Oxygen Model of Alzheimer’s Disease as a unifying model of the disease that has strong explanatory power for all of the clinical, pathologic, and molecular theories and hypothesis that have been proposed to-date. I first published the model in my book entitled “Oxygen and Aging” (2000).
The Oxygen Model Integrates All Theories of Alzheimer’s Disease
Specifically, the Oxygen Model of Alzheimer’s Disease fully integrates and explains the valid aspects of all previously proposed theories of Alzheimer’s disease, including:
1. The cholinergic theory of Alzheimer’s disease holds that AD is caused by reduced synthesis of the neurotransmitter acetylcholine.
2. The amyloid theory of Alzheimer’s disease proposes that a protein called amyloid beta is the primary cause of the disease.
3. The genetic theory of Alzheimer’s disease blames genes for AD, including the APOE4 and chromosome 21.
4. The inflammatory theory of Alzheimer’s disease considers inflammation in the brain as the cause of AD.
5. The immune theory of Alzheimer’s disease considers inflammation in the brain as the cause of AD.
6. The prion theory of Alzheimer’s disease holds prion proteins (linked to mad cow disease and the related human condition called Creutzfeldt-Jakob disease) as the cause of AD.
7. The TAU protein theory of Alzheimer’s disease considers this protein as the cause of AD.
8. The viral theory of Alzheimer’s disease attributes the disease to viruses, such as herpes.
9. The Oxidative Stress Theory of Alzheimer’s disease which I proposed in 1995 in my book entitled “RDA: Rats, Drugs and Assumption.
The Grease and Detergent Model of Alzheimer’s Disease
I include here text from one of my articles entitled “The Grease and Detergent Model of Alzheimer’s Disease“ to illuminate the main tenet of my model. Every living cell breathes oxygen and produces waste and cellular debris. In this process, fats turn rancid, sugars become sticky, and proteins (amino acids threaded together) are turned and twisted, folded and misfolded). In health, these substances are rapidly cleared so that cells can breathe oxygen, expel waste and toxins, and stay healthy and happy. In disease states, rancid fats, sticky sugars, and pulped proteins accumulate on cell membranes. Sometime ago, I introduced the term cellular grease for the layer of such materials that builds on cell membranes in all diseases.
Nature also created a system of grease-cutters—detergents, in common language—that remove cellular grease and allow cells to breathe again. The primary detergent in the human body is oxygen. Secondary detergents are hydrogen peroxide, superoxide, singlet oxygen, nitric oxide, and others. The third layer of detergent is provided by enzymes. The Grease-Detergent Model of Disease explains the beginning of all acquired disease with either excess of grease or deficit of detergents.
Brazen Neglect of Toxicities of Food, Environment, and Thoughts
In their articles, The New England Journal of Medicine and The New York Times assert that that the cause of Alzheimer’s disease is not known. This is most regrettable. These publications do not tell doctors and people that toxicities of foods, environment, and thoughts (stress) can starve brain cells of oxygen and nutrients and kill them. They simply ignore these dangers to the brain cells. They are told to do so by their paymasters (eco-monsters) not to do so. The monsters control the world’s wealth by ruthlessly promoting the disease-causing and disease-maintaining complexes of global banking, energy, chemicals, food production, and drug production. Eco-monsters know money is in insurance companies, hospitals, and drugs, There is no money in teaching people the sciences of nutrition, environment, and stress to prevent disease—Alzheimer’s disease in the present context. I cite hard facts to support my view in an article entitled Oxygen, Alzheimer’s disease, and Lapdog Joes.