Oxygen’s Three-legged Throne

Majid Ali, M.D.

Oxygen’s Three-legged Throne
Taken from Majid Ali’s forthcoming book entitled “The Oxygen Way: Being One’s Own Primary Physician.”

Oxygen occupies the three-legged throne (The “Throne”) of human biology. Insulin serves as its minister of metabolism. The three legs of oxygen’s throne represent the three primary balancing systems of body:

– Acid-alkali balance;
– Oxidant-antioxidant regulation; and
– Clotting-unclotting equilibrium.

Acids are packets of energy—built to store energy and broken down to release energy—used by oxygen to maintain the energy economy of the body. In this model, alkalis can be visualized as mineral compounds that serve many functions in the body as well as provide a counterbalance to acid to maintain an acid-alkali balance. The body acids include breakdown products of fats (fatty acids), proteins (amino acids), starches, and sugars. In chemistry books, acids are defined as sour compounds that form salts with alkalis. However, this aspect of acids is not central to the present context.

Oxidation is the process of loss of electrons (energy particles). Oxidants are substances that oxidize (remove electrons from) other substances. Fresh vegetable juice  becomes stale when left on a kitchen counter for several hours. That occurs because oxygen in the air removes electrons (energy) form the vegetable juice. Anti-oxidants block oxidants and so prevent the loss of electrons (energy).

Oxygen’s Three-legged Throne

The body breaks down foods by a process of oxidation. So oxidation is good. The body also neutralizes poisons by oxidation. That is another example of oxidation being a beneficial process. Premature wrinkling of skin is also cased by oxidative damage to collagen and other skin proteins. Oxidation in this example is harmful. It is crucial to recognize that oxidation is neither good or bad. It is healthful in some reactions and harmful in others. The same holds for oxidants, good under certain conditions and bad under others.

Have you ever seen electrons? Answer: yes, you have. Can you recall the last time you saw electrons? Answer: when you last saw a spark as an electric  plug was pulled out of an electric socket while the appliance was still working. Electric current is a stream of electrons.

Blood and other bodily fluids clot and unclot at all times. Just as a drop of lemon juice curdles milk, excess acids curdle blood, lymph and other bodily fluids. Butter turns rancid when it is left on the counter for hours and becomes oxidized. In the body, cholesterol also becomes oxidized and thickens blood. With high-resolution microscopy, one can see microclot formation when that happens. So, both excess acids and increased free radical activity increase thickening and clotting of the blood and other bodily fluids.

Three Threats to Oxygen’s Throne

The three legs can be visualized as the “executive branches” that serve the king to preserve health—maintain law and order, so to speak—and prevent disease. These legs of the Throne are stressed by three threats:

Toxic foods;
Toxic environments; and

Toxic thoughts.

Blaming genes for diseases, in essence, is accusing parents and disempowering oneself. Besides, there are no gene therapies available for reversing diseases. 

So, in clinical medicine, focus on genetics is misplaced and only adds to confusion and clutter about the causes of nutritional, environmental, metabolic, and stress-related disorders.

The Unifying Oxygen Model of Disease

Any weakness in one leg destabilizes the other legs. For example, excess acidity leads to excess free radical stress and thickens bodily fluids (blood, lymph, and others).  Increased free radical activity causes excess acidity and thickens bodily fluids. Thickened bodily fluids increase acidity and free radical activity. All acquired diseases are initiated and perpetuated by these events. This, in simple words, is the unifying Oxygen Model of Disease.  This model has an enormous explanatory power for understanding the basic nature of the disease processes. The primary strength of this model is that so little explains so much.

 Since all acquired diseases are initiated and perpetuated by disturbances in the three balancing systems of the body, it follows that all such diseases can be reversed only by correcting these disturbances. The Oxygen Model of Disease also has an enormous explanatory power for the healing mechanisms underlying natural, restorative therapies.  In preserving health and reversing disease, the primary strength of the Oxygen Model is that so little explains so much.

The second core point of the analogy is: Two legs of a three-legged stool cannot compensate for a weakness of third leg. The legs of Oxygen’s Three-Legged Throne, by contrast, are living and actively support each other. Each branch of the “oxygen government” senses threats to the others, responding promptly and vigorously to counter that threat and maintain order. Thus, the OAR branch senses and responds to excess acidity and  increased clottability of bodily fluids, countering the effects of dysfunction in those two branches. The AAB branch senses and responds to disorder in OAR and CUE. Likewise, the CUE branch senses and responds to disorder in AAB and OAR systems.

The Dysox State

In 1998, I coined the term dysox (short for dysfunctional oxygen metabolism (dysoxygenosis) for a state of disturbed oxygen homeostasis. The term homeostasis refers to integration, balancing, and regulation of all aspects of a living system. Specifically, I introduced the term dysox collectively for a broad range of disruptions, including:

 -Oxygen-driven cellular energetics;
-Oxygen-driven detox pathways;
-Oxygen signaling for cellular development;

 -Oxygen signaling for cellular differentiation;

 -Oxygen signaling for cellular demise;
-Oxygen detergent functions.

The 3-M Model of Cellular Injury


 Derangements of oxygen homeostasis have most pronounced effects on three types of structures: membranes, matrix, and mitochondria. I call it the 3-M Model of Cellular Injury. 

The cell membrane separates an internal order from an external disorder. Reading its environment, it transmits valuable information to cell innards and selectively admits nutrients and expels waste. Among its crucial gating functions are the transfer in and out of the cell of minerals, such as calcium, magnesium, potassium, and sodium.

 Matrix is the cement substance (glue) that holds cells together. It exerts life-and-death regulatory influences on cells. Mitochondria are structures within cells that generate ATP energy. For professional readers, I describe the various aspects of the 3-M Model of Disease in Darwin, Oxygen Homeostasis, and Oxystatic Therapies (2009), the tenth, volume of my textbook entitled The Principles and Practice of Integrative Medicine. 
Darwin and  Dysox Trilogy

A Workable Simplicity

Oxygen is the organizing principle of human biology and governs the aging process. I began my book Oxygen and Aging(2000) with these words. I followed that volume with a series of articles in which I marshaled evidence for the unifying Oxygen Model of Disease, specifically oxygen models of inflammation, pain, liver injury, asthma, allergy, colitis, heart disease, stroke, kidney failure, cancer, and other disorders. The crucial importance of  the unifying Oxygen Model of Disease is:

  -It explains the primary aging processes in the body;
-It sheds light on how health can be preserved by addressing all oxygen-related issues;
-It elucidates how toxicities of foods, environments, and thoughts cause disease;
-It allows the formulation of rational and effective designs for reversing chronic disease can be developed; and
-It provides mechanisms by which time-honored natural remedies work.

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