Female Testosterone Toxicity Syndrome (FTTS)


Majid Ali, M.D.

In this article I introduce the term “Female Testosterone Toxicity State (FTTS) to sharply focus on what I see to an epidemic of testosterone toxicity in girls and women of all ages. With increasing frequency I see testosterone toxicity in girls and young women after they have seen pediatricians, gynecologists, and endocrinologists. Amazingly, when I review their records, I do not find the results of blood testosterone and insulin tests, the two tests that tell the whole story. Years later, such girls and women are diagnosed with polycystic ovary syndrome (PCOS).

Cystless Polycystic Ovary Syndrome

Sometime ago, I introduced the term “Cystless PCOS (Polycystic Ovary Syndrome Without Cysts to underscore the essential metabolic toxicity nature of the problem. Below is some text from that article:

“There is a disturbing rise in the incidence of insulin toxicity associated with hormonal and metabolic derangements in young girls and women. Equally disturbing is how often such cases are grossly mismanaged by their pediatricians and gynecologists. To address these problems, in this article, I introduce the term “Cystless PCOS (Polycystic Ovary Syndrome Without Cysts).” With this term I want to underscore the importance of early recognition of a symptom-complex caused by insulin toxicity and excess testosterone and unaccompanied by bilateral ovarian cysts. The clinical features of Pre-PCOS include facial and chest hair, acne, menstrual abnormalities, loss of menstruation, weight gain, fatigue, and problems of mood, memory, and mentation. All my patients with Cystless PCOS had allergy and recurrent upper respiratory infections for which they received multiple courses of antibiotics. Some of them also suffered from asthma and had received multiple courses of steroids. “

“The importance of recognizing this as a specific condition is that the failure to detect ovarian cysts on pelvic ultrasound does not lead to inadequate diagnostic testing (missed detection of insulin toxicity) and neglect of the crucial hormonal and metabolic derangements. Recently, The England Journal of Medicine recommended the use of Metformin (which not only ignores the real issue of insulin toxicity but actually worsens the problem in the long run).”

One face of Female Testosterone Toxicity Syndrome (FTTS)

* Course on Testosterone 

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